lncRNAs #

In general, only ~5% of the mRNA transcripts codes for protein. The rest are remaining as other kind of RNAs (lncRNA, miRNA, siRNA, piRNA etc). For example mouse transcriptome contains ~180,000 transcripts, but only ~20000 protein coding genes were identified.

Long non-coding RNA (lncRNA) is longer than 200 nucleotides (<70–100 amino acids) in length. Although lncRNAs do not encode proteins, these RNA sequences are important for epigenetic inheritance, transcription, post-transcription, and other multi-level regulatory processes. In addition to mRNA and microRNA, lncRNA is a major hotspot in functional genomics research.

Potential functions #

• Transcriptional interference
• Induce chromatin remodeling and histone modifications
• Control alternative splicing patterns
• Modify protein activity
• Alters protein localization in the cell

In silico approaches to identify lncRNAs #

• cDNA/EST in silico mining
• Whole genome tilling array
• RNA-seq
• Epigenetic signature-based methods

How to study lncRNAs #

lncRNA and Cancer #

lncRNAs represent an emerging and under-studied class of transcripts that play a significant role in human cancers. Due to the tissue- and cancer-specific expression patterns observed for many lncRNAs it is believed that they could serve as ideal diagnostic biomarkers.

Useful links #

• http://lncrnadb.org/
• http://www.lncrnablog.com/
• http://lncrnator.ewha.ac.kr/index.htm
• http://chualab.rockefeller.edu/gbrowse2/homepage.html
• http://www.bioinfo.org/noncode/index.php

Incoming Links #

Related Bioinformaticses (Bioinformatics 0) #

• CNCI
• PlncRRO

Suggested Pages #

• 0.551 Peptide functional annotations
• 0.449 Machine Learning/Peptide functional annotations
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