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NHLBI Grand Opportunity Exome Sequencing Project (ESP) #

NHLBI GO(Grand Opportunity) Exome Sequencing Project (ESP,는 단백질을 코딩하는 엑손 영역을 NGS로 시퀀싱하여 심장, 폐 및 혈액 질환에 관여하는 새로운 유전자와 매커니즘을 발굴하기 위한 프로젝트이다. 이 프로젝트에 참여하는 그룹은 아래와 같다.

  • Seattle GO - University of Washington, Seattle, WA
  • BroadGO - Broad Institute of MIT and Harvard, Cambridge, MA
  • WHISP - Ohio State University Medical Center, Columbus, OH
  • Lung GO - University of Washington, Seattle, WA
  • WashU GO - Washington University, St. Louis, MO
  • Heart GO - University of Virginia Health System, Charlottesville, VA
  • ChargeS GO - University of Texas Health Sciences Center at Houston

연구대상은 미국 내에 가장 많이 분포하고 있는 20만명 이상의 인구 집단에서 발병하는 질환들을 포함한다.

  • Women's Health Initiative (WHI)
  • Framingham Heart Study (FHS)
  • Jackson Heart Study (JHS)
  • Multi-Ethnic Study of Atherosclerosis (MESA)
  • Atherosclerosis Risk in Communities (ARIC)
  • Coronary Artery Risk Development in Young Adults (CARDIA)
  • Cardiovascular Health Study (CHS)
  • Lung Health Study (LHS)
  • COPD Genetic Epidemiology (COPDGene)
  • Severe Asthma Research Project (SARP)
  • Pulmonary Arterial Hypertension (PAH)
  • Acute Lung Injury (ALI)
  • Cystic Fibrosis (CF)
  • PennCATH
  • Cleveland Clinic Genebank
  • Massachusetts General Hospital Premature Coronary Artery Disease Study (MGH PCAD)
  • Heart Attack Risk in Puget Sound (HARPS)
  • Translational Research Underlying Disparities in Myocardial Infarction Patients' Health Status (TRIUMPH)

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