개요 #

ESCAPE는 Embryonic Stem Cells Atlas of Pluripotency Evidence의 약자로 배아줄기세포의 자료를 모아둔 데이터베이스이다. 유전체 수준의 단백질 상호작용, miRNA 네트워크, TF 네트워크, 유전자 발현 데이터, RNAi 스크리닝 결과 등을 raw 데이터 및 가공한 시각화 결과를 제공한다. 본 데이터베이스는 배아줄기세포 기전 이해를 위한 시스템생물학 연구에 유용한 중요한 참고자료로 활용가능하다.

웹사이트 #

http://www.maayanlab.net/ESCAPE/

DB현황 #

• 206,521 interactions from Chip-seq/chip studies
• 153,920 interactions from logof followed by microarrays
• 1,037 protein protein interactions
• 693,552 miRNA target interactions
• 813 Putative pluripotency genes determined by RNAi screens
• 19,801 Undifferentiated and differentiating ESC specific proteins
• 16,881 histone modifications determined by Chip-seq/chip
• 8,323 Undifferentiated and differentiating ESC specific phosphoproteins from phosphoproteomics
• 9 genome-wide mRNA expression profile summaries
• 3,136 miRNA expression entries
• 14,105 time course expression entries from J1 #1
• 17,022 time course expression entries from J1 #2
• 14,105 time course expression entries from R1 #1
• 17,022 time course expression entries from R1 #2
• 14,668 time course expression entries from V6.5 #1
• 17,022 time course expression entries from V6.5 #2
• 14,698 time-course expression entries of shRNAi #1
• 18,265 time-course expression entries of shRNAi #2

논문 #

Xu H, Baroukh C, Dannenfelser R, Chen EY, Tan CM, Kou Y, Kim YE, Lemischka IR, Ma'ayan A. ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells. Database (Oxford). 2013 Jun 21